Which type of local anesthetics is metabolized primarily in the liver?

Amide-type local anesthetics are primarily metabolized in the liver. This characteristic is essential for understanding the pharmacokinetics of these drugs. In contrast, ester-type local anesthetics are typically metabolized by plasma cholinesterases found in the bloodstream, leading to a different profile regarding their duration of action and potential for systemic toxicity.

Amides have a longer duration of action due to their hepatic metabolism, allowing for a more prolonged anesthetic effect, which is often beneficial in dental procedures. They are generally more stable and less likely to cause allergic reactions compared to esters. Understanding the metabolic pathways and potential side effects associated with the different classes of local anesthetics is crucial for safe and effective clinical practice, especially in managing patient care and systemically administering these anesthetics.